FIGURE 4.

General mechanisms for controlling and coordinating the expression of RPGs. The illustrated schematics depict the basic principles guiding the control of RPG expression. In this hypothetical model, the RPGs will respond collectively to changes in the amount of mature rRNA and signals for global repression of ribosome synthesis transcription repression guided by common promoter elements. On the other hand, gene specific regulation required for adjusting the dose of duplicated RPGs and genes playing extra‐ribosomal roles may take place through regulation of splicing, RNA stability, transcription termination, and translation. A, P, and U indicates examples of modifications of RPs through acetylation, phosphorylation, and ubiquitination