TABLE 1.

Search strategy adopted in present systematic review

Search strategy item	Search strategy details
String of keywords	(“actinic keratosis” OR “solar keratosis” OR “senile keratosis”) AND (safety OR tolerability OR satisfaction OR “quality of life” OR “patient satisfaction” OR “patient‐reported outcome” OR PRO OR “patient‐reported outcome measure” OR PROM OR “patient perspective” OR “patient preference” OR “patient perception”)
Database searched	PubMed/MEDLINE
Time filter	None applied (from inception)
Language filter	None applied (any language)
Inclusion criteria	P (patients suffering from AK) I (intervention, medical field treatment for AK, such as imiquimod, diclofenac, ingenol mebutate) C (comparison) all the articles reporting medical therapy for AK, independently from the comparison with another drug or placebo O (outcomes, including PROs/PROMs) S (study design, any study design) Publication type: original study
Exclusion criteria	P (patients not suffering from AK) I (intervention, nonmedical treatment for AK, such as surgery, cryo‐therapy or photodynamic therapy) C (comparison, with nonmedical treatment for AK) O (outcomes other than PROs/PROMs, such as clinical outcomes) S (study design) Publication type (expert opinions, comments, commentaries, letters to editor, editorials, reviews)
Hand‐searched target journals	Actas Dermosifiliogr; Clin Cosmet Investig Dermatol; Dermatology; Dermatol Ther (Heidelb); J Am Acad Dermatol; J Eur Acad Dermatol Venereol