Table 1.
Baseline characteristics of patients undergoing thrombectomy with DA first-line versus SR first-line.
| Baseline variable | DA first-line (n = 102) | SR first-line (n = 1123) | p-Value |
|---|---|---|---|
| Age, median (IQR), years | 65 (54–74) | 65 (55–73) | 0.61 |
| Male sex | 63 (61.8) | 712 (63.4) | 0.74 |
| History of hypertension | 56 (54.9) | 633 (56.4) | 0.78 |
| History of diabetes mellitus | 21 (20.6) | 194 (17.3) | 0.40 |
| History of dyslipidemia | 10 (9.8) | 98 (8.7) | 0.71 |
| History of coronary heart disease | 17 (16.7) | 175 (15.6) | 0.77 |
| History of atrial fibrillation | 39 (38.2) | 381 (33.9) | 0.38 |
| Prior stroke | 20 (19.6) | 234 (20.8) | 0.77 |
| Cigarette smoking | 0.61 | ||
| Never smoker | 64 (62.8) | 706 (62.9) | |
| Ex-smoker | 9 (8.8) | 72 (6.4) | |
| Current smoker | 29 (28.4) | 345 (30.7) | |
| Systolic blood pressure, median (IQR), mmHg | 148 (135–160) | 145 (130–161) | 0.63 |
| NIHSS score, median (IQR) | 16 (12–19) | 17 (13–22) | 0.17 |
| ASPECTS, median (IQR)a | 9 (7–10) | 9 (7–10) | 0.21 |
| Occlusion site | <0.01 | ||
| Internal carotid artery | 51 (50.0) | 263 (23.4) | |
| Middle cerebral artery (M1) | 34 (33.3) | 510 (45.4) | |
| Vertebro-basilar artery | 15 (14.7) | 224 (20.0) | |
| Other intracranial arteries | 2 (2.0) | 126 (11.2) | |
| Tandem lesions | 36 (35.3) | 163 (14.5) | <0.01 |
| Underlying ICAD | 0.12 | ||
| Yes | 21 (20.6) | 333 (29.7) | |
| No | 66 (64.7) | 666 (59.3) | |
| Undetermined | 15 (14.7) | 124 (11.0) | |
| Stroke subtype by TOAST criteria | 0.02 | ||
| Large artery atherosclerosis | 33 (32.4) | 506 (45.1) | |
| Cardioembolism | 49 (48.0) | 397 (35.4) | |
| Other or unknown etiology | 20 (19.6) | 220 (19.6) | |
| Prior use of antiplatelet agents | 16 (15.7) | 170 (15.1) | 0.88 |
| Prior use of anticoagulants | 7 (6.9) | 51 (4.5) | 0.32 |
| Prior intravenous thrombolysis | 45 (44.1) | 291 (25.9) | <0.01 |
| Intra-procedural use of heparin | 43 (42.2) | 574 (51.1) | 0.08 |
| Type of anesthesia | 0.11 | ||
| Local anesthesia only | 35 (34.3) | 477 (42.5) | |
| Local anesthesia plus sedation | 14 (13.7) | 183 (16.3) | |
| General anesthesia | 53 (52.0) | 463 (41.2) | |
| Onset-to-puncture time, median (IQR), min | 318 (210–425) | 300 (212–440) | 0.97 |
Values are numbers with percentages in parentheses, unless indicated otherwise.
a
ASPECTS for anterior circulation stroke; and pc-ASPECTS for posterior circulation stroke.
ASPECTS, Alberta stroke program early CT score; DA, direct aspiration; ICAD, intracranial atherosclerotic disease; IQR, interquartile range; NIHSS, National Institutes of Health Stroke Scale; pc-ASPECTS, posterior circulation Alberta stroke program early CT score; SR, stent retriever; TOAST, Trial of ORG 10172 in Acute Stroke Treatment.