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. 2021 Feb 2;296:100362. doi: 10.1016/j.jbc.2021.100362

Figure 2.

Figure 2

Deletion of calcium-sensor activators of guanylyl cyclase rescues rd3/rd3 photoreceptors.A, representative retinal morphology at 2.5 months of age in wildtype, rd3/rd3, GCAP1-/-rd3/rd3, GCAP2-/-rd3/rd3, and GCAP1,2−/−rd3/rd3; hereafter, the retinal histological layers are referred to as RPE (retinal pigment epithelium), ROS (rod outer segments), ONL (outer nuclear layer), OPL (outer plexiform layer), INL (inner nuclear layer), IPL (inner plexiform layer), and GCL (ganglion cell layer). The photoreceptor layer thickness between the retinal pigment epithelium and outer plexiform layer is highlighted in yellow. B, photoreceptor nuclei count in the outer nuclear layer at 2.5 months in wildtype (◇), rd3/rd3 (○), GCAP1-/-rd3/rd3 (▲), GCAP2-/-rd3/rd3 (□), and GCAP1,2−/−rd3/rd3 (♦); each data point is from a different mouse. The differences were tested using ANOVA (F = 158, p < 0.0001); the p-values shown in the graph are from the Tukey’s HSD post hoc comparison (hereafter, confidence level 99%, alpha = 0.01). GCAP, guanylyl cyclase activating protein.