Table 2:

Mean levels of MetS severity and liver-related factors^a

	Overall	Normal ALT, No Elevated NFS	Unexplained elevated ALT,b without advanced fibrosis	Elevated ALT above 97.5%tile without advanced fibrosis	Fibrosis stage 3 or 4c	Elevated NFS and Fib4 d
MetS & insulin resistance
MetS-Z	0.2 [0.2, 0.3]	0.1 [0.1, 0.2]	0.7 [0.6, 0.8]	0.8 [0.7, 1.0]	1.7 [1.5, 1.9]	0.6 [−0.1, 0.7]
No-glucose MetS-Z	0.1 [0.1, 0.1]	0.0 [0.0, 0.04]	0.5 [0.5, 0.6]	0.6 [0.4, 0.8]	0.8 [0.7, 1.0]	0.2 [−0.4, 0.7]
Insulin	9.8 [9.4, 10.1]	8.8 [8.5, 9.1]	15.1 [13.9, 16.3]	14.8 [12.5, 17.0]	25.6 [17.1, 34.2]	24.7 [3.7, 45.8]
HOMA-IR	2.7 [2.6, 2.8]	2.3 [2.3, 2.4]	4.5 [4.0, 4.9]	4.4 [3.6, 5.2]	8.8 [6.1, 11.5]	6.5 [2.1, 10.8]
Liver and other factors
ALT	25.4 [24.9, 25.8]	21.5 [21.3, 21.7]	54.9 [52.6, 57.1]	93.0 [86.5, 99.1]	26.7 [22.4, 30.9]	31.8 [19.5, 44.1]
AST	24.3 [24.0, 24.6]	22.3 [22.1, 22.5]	39.3 [37.3, 41.4]	64.1 [56.5, 71.6]	28.4 [23.5, 33.2]	56.7 [26.0, 87.4]
ALT :AST ratio	1.1 [1.0, 1.1]	1.1 [1.1, 1.1]	0.7 [0.7, 0.8]	0.7 [0.6, 0.8]	1.1 [1, 1.2]	1.8 [1.2, 2.3]
GGT	25.5 [24.7, 26.3]	22.7 [22.0, 23.4]	45.2 [41.8, 48.5]	62.2 [50.5, 74.0]	41.3 [32.1, 50.5]	84.9 [27.3, 142.5]
hsCRPe	0.4 [0.4, 0.4]	0.4 [0.4, 0.4]	0.5 [0.4, 0.5]	0.4 [0.4, 0.5]	0.7 [0.5, 0.9]	1.0 [0.1, 1.9]
NFS	−2.4 [−2.5, −2.4]	−2.5 [−2.5, −2.4]	−2.6 [−2.7, −2.5]	−2.7 [−3.0, −2.4]	1.3 [1.1, 1.4]	1.8 [1.3, 2.2]

^a.Presented: Means [95% CI]

^b.ALT >40 in males and >31 in females [12]

^c.NASH Fibrosis Score > 0.676

^d.NASH Fibrosis Score > 0.676 and Fib4 > 2.67

^e.n missing/not reported = 777