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. 2021 Apr 14;9:70. doi: 10.1186/s40478-021-01172-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Comparison of mbPEGQ30 peptide recruitment and S830 antibody staining on brain sections from zQ175 mice and their wild-type littermates. a Coronal-hemispheres from 5-month-old zQ175 mice and their wild-type littermates, either treated with the mbPEGQ30 peptide or immunolabelled with the S830 antibody (2.5 ×). b Zoomed-in view of cortical, striatal and hippocampal (CA1) regions from 5-month-old zQ175 and wild-type mice, either treated with the mbPEGQ30 peptide or immunolabelled with S830. Black arrows in b point to the defined puncta of the recruitment signal. Purple arrows indicate the diffuse nuclear aggregation; blue arrowheads point to small inclusion bodies. WT = wild-type. Scale bars: a 400 μm; b 10 μm