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. 2021 Apr 14;9:70. doi: 10.1186/s40478-021-01172-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Co-localization of HTT-exon1-43Q signal with S830 antibody immunostaining. a HTT-exon1-43Q (green) was applied to TrueBlack treated zQ175 and wild-type brain sections from 6-month-old mice which were immunoprobed with the S830 antibody (magenta) and nuclei were counterstained with Hoechst (blue). HTT-exon1-43Q was recruited to perinuclear inclusions in the striatum, cortex, and hippocampus (CA1). b R6/2 and wild-type brain sections from 12-week-old mice treated with the HTT-exon1-43Q protein were immunoprobed with S830 and nuclei were counterstained with Hoechst. HTT-exon1-43Q was recruited to perinuclear inclusions as shown in the hippocampal CA1 region. c Enlarged areas from white boxed regions in a and b, respectively. The intensity profiles were plotted along the white dotted lines. The HTT-exon-43Q protein was not recruited to nuclear inclusions. Scale bars: 10 μm. WT = wild-type