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. 2021 Apr 14;9:70. doi: 10.1186/s40478-021-01172-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Recruitment of exon 1 HTT proteins to brain sections from HD mouse models is disease-stage and polyQ-length dependent. a Representative confocal microscopy images for recruitment of HTT-exon1-43Q to the hippocampus (CA1) of R6/2 and wild-type mice at 4, 8 and 12 weeks of age. Nuclei were counterstained with Hoechst. b Recruitment of HTT-exon1-15Q, HTT-exon1-23Q and HTT-exon1-43Q, as well as HTT-exon1-43Q with an N-terminal 17 amino acid truncation (ΔN17-exon1-43Q) to 6-month-old zQ175, and 12-week-old R6/2, brain sections. Nuclei were counterstained with Hoechst. c Quantification of fluorescence intensities of HTT-exon1-43Q treatment for R6/2 and wild-type mice at 4, 8 and 12 weeks of age. d, e Quantifications of fluorescence intensities of d zQ175 and e R6/2 sections treated with exon 1 HTT proteins with different polyQ lengths. The fluorescence intensities were normalized to the wild-type control. Statistical analysis was by two-way ANOVA. Data represented by mean ± S.D., two sets of 15–25 images for three replicates per experiment. *p < 0.05; **p < 0.01; ***p < 0.001, ns = not significant. Scale bars: 20 μm. WT = wild-type