Fig. 7.

The recruitment organelles are members of a dysregulated endolysosomal system. a–e Confocal images of the CA1 region from 6-month-old zQ175 mice showing that HTT-exon1-43Q was recruited to organelles that were also immunostained with an antibody to LAMP1 and with S830. White arrowheads in a–d indicate the same three regions across different channels. e Merged image of all channels from a–d. The three dotted lines run through the puncta indicated by the arrowheads. f Intensity profiles showing the signal along the dotted lines (from left to right) in e. Scale bars: 10 μm