Table 2.

Predictive factors of shorter OS (n = 101)

Variables	Univariate analysis		Multivariate analysis
	HR	P-value	HR	95% CI	P-value
Sex, male	1.209	0.282
Age	1.007	0.344
Primary tumor
Location, colon/rectum	0.888	0.503
Location, right-sided/left-sided	0.818	0.385
pT stage	1.274	0.092
Positive lymph node	1.426	0.062
Initial liver metastases
Timing of diagnosis: synchronous	1.405	0.050	1.186	0.669–2.144	0.562
Tumor distribution: bilobar	1.642	0.005	1.106	0.594–2.103	0.752
No. of tumors	1.072	0.001
No. of tumors (solitary/multiple): multiple	2.050	< 0.001	1.010	0.523–2.436	0.807
Tumor size ≥5 cm	2.122	< 0.001	1.092	0.541–2.125	0.801
Serum carcinoembryonic antigen ≥5 ng/mL	1.586	0.029	1.964	0.991–4.188	0.053
Type of hepatectomy: major	1.812	0.002	1.415	0.762–2.586	0.268
Surgical margin: R1	1.805	0.002	2.554	1.385–4.750	0.003
KRAS mutational status: KRAS-mut	1.860	0.026	2.409	1.361–4.250	0.003

HR Hazard ratio; CI Confidence interval