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. 2021 Apr 14;13:58. doi: 10.1186/s13073-021-00871-5

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© The Author(s) 2021, corrected publication 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — PRMT1 and SMARCA4 cooperatively activate TNS4 and EGFR transcription in HCT116 cells. a, b Quantitative real-time PCR analysis of indicated mRNAs normalized to GAPDH (a) and western blot analysis of indicated proteins normalized to histone H4 and Hsp70 (b) from HCT116 cells that had been transfected with EV (empty vector, MSCV) or PRMT1-WT, and transfected or not with a SMARCA4 expression construct. c, d Quantitative real-time PCR analysis of indicated mRNAs normalized to GAPDH (c) and western blot analysis of indicated proteins normalized to histone H4 and Hsp70 (d) from NC or PRMT1-KD in HCT116 cells transfected or not with a SMARCA4 expression construct. e, f Quantitative real-time PCR analysis of indicated mRNAs normalized to GAPDH (e) and western blot analysis of indicated proteins normalized to histone H4 and Hsp70 (f) from HCT116 cells transfected with PRMT-WT or PRMT1-Δ constructs and transfected or not with a SMARCA4 expression construct. For a, c, and e, results are shown as mean ± s.d. from three independent experiments; *P < 0.05, **P < 0.01 compared with the indicated control