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. 2021 Apr 14;16:25. doi: 10.1186/s13024-021-00442-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — AIF3 induced neurodegeneration of Purkinje cells in cerebellum. a Expression of CamKIIα-iCre in Purkinje cells indicated by td-Tomato. CamKIIα-iCre mouse was crossed with a Cre reporter Td-Ai14 mouse. The expression of iCre was indicated by td-Tomato and Purkinje cells indicated by Calbindin in 6-month-old mouse. Top panel: overview; Bottom panel: magnification of the box region. Scale bar: 200 μM. b Calbindin immunostaining in 3-month-old AIF3 splicing mice (AIF^fl/Y/CamKIIα-iCre+) and littermate control AIF mice (AIF^fl/Y/CamKIIα-iCre-). The arrows indicate calbindin-positive Purkinje cells. Scale bar, 200 μm. Representative images are from at least three independent experiments. c Quantification of the relative Purkinje neuron number per field in the cerebellum of AIF and AIF3 splicing mice. Data are shown as mean ± S.E.M. and analyzed for statistical significance by Student t test. n = 5. ****p < 0.0001