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. 2021 Apr 14;16:25. doi: 10.1186/s13024-021-00442-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — AIF3 splicing caused progressive neurodegeneration in the forebrain. a Representative Nissl staining images of cortex and hippocampus in AIF3 splicing mice (AIF^fl/Y/CamKIIα-iCre+) and littermate control AIF mice (AIF^fl/Y/CamKIIα-iCre-) at P20, P60 and P90 days. Scale bar, 200 μm. b Quantification of neuron loss regions in AIF3 splicing cortex and hippocampus vs. WT cortex and hippocampus respectively at P20, P60 and P90. Data are shown as mean ± S.E.M Data are shown as mean ± S.E.M and analyzed for statistical significance by one-way ANOVA. n = 5. ****p < 0.0001; *p < 0.05