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. 2021 Feb 9;128(8):1156–1169. doi: 10.1161/CIRCRESAHA.120.316966

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© 2021 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 4. — Proteins differentially expressed in NAA15^+/− and NAA15^−/− induced pluripotent stem cells (iPSCs). A, Scatterplot displays log2 fold changes of differentially expressed proteins in NAA15^+/− and NAA15^−/− iPSCs compared with wildtype (WT) iPSCs. Approximately 1200 proteins are differentially expressed, 9 and 3 proteins of which have reduced Nt-acetylation in NAA15^−/− iPSCs and NAA15^+/− iPSCs, respectively. Data was collected from 2 independent undifferentiated iPS cell lines for each NAA15 (N-alpha-acetyltransferase 15) mutant genotype and at least 3 technical replicates for each sample. B, Comparison of differentially expressed proteins in NAA15^−/− and NAA15^+/− iPSCs. Differential expression was considered for log2 fold change |1|. Identified proteins: 5196, quantified proteins: 3911 proteins detected by mass spectrometry (C) gene ontology (GO) enrichment of differentially expressed proteins in both NAA15^−/− and NAA15^+/− iPSCs. A total of 41 proteins are localized to the ribosome. Raw P value presented in data table. D, Bar graph represents log2 fold change of ribosomal proteins that are differentially expressed in both NAA15^−/− and NAA15^+/− iPSCs.