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. Author manuscript; available in PMC: 2022 Apr 4.
Published in final edited form as: Chem Commun (Camb). 2021 Mar 1;57(26):3227–3230. doi: 10.1039/d1cc00095k

Fig. 3.

Fig. 3

Non-covalent interactions and pKa depression contribute to RPI rate enhancement. (a) Comparison of the pKa of the peptide 1’s Cys thiol with that of a control peptide (S3). (b) Proposed RPI mechanism of action.