TABLE 1:

Summary of T-cell phenotypes in knockout mice lacking DNMT or TET enzymes

Gene	Cre/mutation type	T-cell phenotype	Reference
DNMT1	Hypomorph	Decreased lymphoid commitment	Broske et al., 200966
	LckCre	Profound loss of DP and SP thymocytes; increased apoptosis	Lee et al., 200171
	CD4Cre	Normal thymocyte development; slight ↓ in CD44hi peripheral CD4+ and CD8+ T-cells; decreased proliferation Increased cytokine production
DNMT3A	Germline KO	Runted, die by 4 weeks ↓ thymocyte cellularity, partial DN → DP block	Okano et al., 19994 Gamper et al., 200972
	CD4Cre	No thymocyte defects noted Normal TH1 and TH2 in vitro differentiation, increased plasticity	Gamper et al., 200972
TET1/TET2	TET1 KO; TET2 CD4Cre	Increased FoxP3 promoter and CNS2 methylation Loss of Treg stability and suppressive function	Yang et al., 2015106
TET2/TET3	CD4Cre	Expansion of NKT17 cells Fatal antigen-dependent iNKT lymphoproliferative disorder	Tsagaratou et al., 201776
	FoxP3Cre	Diminished demethylation of FoxP3 CNS2 and TSDRs of other genes Impaired long-term stability, increase in ‘ex-Tregs’ Lethal inflammatory disease	Yue et al., 2019105
TET2	CD2Cre	↓ TH1 and TH17 in vitro differentiation Altered cytokines in EAE model	Ichiyama et al., 201578
	CD4Cre	↑ central memory CD8+ T-cell differentiation	Carty et al., 201836