FIGURE 6.

Sex differences in carbachol effects on dentate granule cells. Data from ARR and ENT animals were combined to show that overall, cells from both males and females depolarized under carbachol application (a1). When these data are parsed out by rhythm status (a2), no carbachol‐induced depolarization was seen in either female or male ENT animals. Significant depolarization by carbachol was detected, however, in cells from both male and female ARR animals (a2). The resting membrane potential was greater in cells from male ARR compared to those from male ENT animals (a2). We found no significant sex differences in the proportion of cells that were reactive to carbachol (p > .05; b). Frequency distributions of spontaneous IPSP intervals (c1) and amplitudes (c2) during the first 150 s of recording. Statistical comparisons were made with KS tests from cumulative frequency distributions of the data in panels (c1) and (c2). There were no sex differences in control conditions (p > .05). Carbachol increased the number of spontaneous IPSP events in females (p = .021), but not in males (p > .05). There were no significant differences (p > .05) in amplitudes (c2) of spontaneous ISPS events. Box plot parameters as in Figure 4. *p < .05