TABLE 3.
Multivariable HRs and 95% CIs of the PCs for total BCL and major subtypes mutually adjusted for other PCs
| BCL | CLL | FL | DLBCL | MM | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PC | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P |
| 1 | 0.94 (0.89‐0.99) | .03 | 0.94 (0.84‐1.05) | .26 | 0.96 (0.84‐1.10) | .58 | 0.97 (0.87‐1.10) | .66 | 0.91 (0.82‐1.01) | .08 |
| 2 | 1.03 (0.98‐1.08) | .27 | 1.10 (0.99‐1.21) | .07 | 0.97 (0.85‐1.10) | .63 | 0.98 (0.88‐1.10) | .79 | 1.01 (0.92‐1.10) | .91 |
| 3 | 0.99 (0.95‐1.03) | .65 | 0.99 (0.90‐1.08) | .75 | 0.94 (0.85‐1.05) | .31 | 1.01 (0.92‐1.11) | .78 | 0.99 (0.91‐1.07) | .82 |
| 4 | 1.03 (0.99‐1.08) | .17 | 1.00 (0.91‐1.11) | .95 | 1.02 (0.91‐1.15) | .73 | 0.99 (0.90‐1.11) | .94 | 1.06 (0.98‐1.16) | .16 |
| 5 | 1.09 (1.04‐1.15) | .0001 | 1.06 (0.96‐1.18) | .25 | 1.02 (0.89‐1.16) | .78 | 1.15 (1.03‐1.28) | .01 | 1.18 (1.07‐1.29) | .0001 |
| 6 | 1.00 (0.95‐1.05) | .97 | 0.91 (0.81‐1.02) | .10 | 0.94 (0.82‐1.08) | .42 | 0.96 (0.85‐1.08) | .48 | 1.06 (0.96‐1.16) | .25 |
| 7 | 1.04 (1.00‐1.09) | .04 | 1.01 (0.92–1.10) | .89 | 1.09 (0.98‐1.20) | .11 | 1.12 (1.03‐1.22) | .01 | 1.02 (0.94‐1.10) | .62 |
| 8 | 1.00 (0.96‐1.05) | .90 | 0.98 (0.89‐1.07) | .61 | 0.95 (0.85‐1.06) | .39 | 1.05 (0.95‐1.15) | .33 | 1.00 (0.92‐1.08) | .95 |
| 9 | 1.03 (0.99‐1.07) | .20 | 1.04 (0.96‐1.14) | .31 | 1.08 (0.97‐1.20) | .15 | 1.02 (0.93‐1.12) | .67 | 0.98 (0.90‐1.06) | .62 |
| 10 | 1.06 (1.02‐1.11) | .01 | 1.07 (0.98‐1.17) | .14 | 1.10 (0.98‐1.22) | .10 | 1.12 (1.02‐1.22) | .02 | 1.07 (0.98–1.16) | .13 |
| 11 | 1.04 (0.99–1.08) | .07 | 0.98 (0.90‐1.08) | .74 | 1.13 (1.03‐1.25) | .01 | 1.06 (0.97‐1.16) | .18 | 1.02 (0.94–1.10) | .67 |
| 12 | 1.05 (0.99‐1.13) | .13 | 1.06 (0.92‐1.22) | .43 | 1.02 (0.86‐1.21) | .82 | 1.09 (0.94‐1.26) | .25 | 1.09 (0.95‐1.23) | .21 |
| 13 | 1.04 (0.98‐1.10) | .19 | 1.01 (0.89‐1.15) | .86 | 1.02 (0.87‐1.18) | .82 | 1.12 (0.98‐1.27) | .08 | 1.07 (0.96‐1.19) | .21 |
| 14 | 0.98 (0.94‐1.02) | .24 | 0.98 (0.90‐1.07) | .64 | 0.92 (0.82‐1.03) | .16 | 0.99 (0.90‐1.09) | .81 | 1.03 (0.95‐1.11) | .50 |
| 15 | 0.99 (0.95–1.05) | .86 | 1.04 (0.94‐1.16) | .45 | 1.06 (0.94‐1.20) | .35 | 0.86 (0.76‐0.98) | .02 | 1.05 (0.96–1.16) | .27 |
| 16 | 1.02 (0.97‐1.08) | .37 | 1.05 (0.94‐1.17) | .37 | 1.08 (0.94‐1.23) | .28 | 1.01 (0.90‐1.14) | .81 | 0.97 (0.88‐1.07) | .59 |
| 17 | 0.95 (0.90‐1.00) | .06 | 0.91 (0.81‐1.03) | .12 | 0.95 (0.82‐1.09) | .47 | 1.02 (0.91–1.15) | .69 | 0.91 (0.82‐1.02) | .10 |
| 18 | 0.99 (0.95‐1.04) | .83 | 1.01 (0.92–1.11) | .83 | 1.00 (0.89‐1.13) | .96 | 1.05 (0.96‐1.15) | .28 | 0.95 (0.86‐1.04) | .25 |
| 19 | 1.00 (0.96–1.05) | .99 | 0.96 (0.88‐1.06) | .46 | 1.03 (0.92‐1.16) | .56 | 1.02 (0.92‐1.12) | .76 | 1.00 (0.92‐1.09) | .97 |
| 20 | 0.98 (0.94–1.02) | .37 | 0.94 (0.85‐1.03) | .17 | 0.97 (0.87‐1.08) | .61 | 0.92 (0.83‐1.02) | .11 | 1.03 (0.95‐1.13) | .43 |
| 21 | 1.01 (0.97‐1.05) | .53 | 1.03 (0.95–1.11) | .47 | 0.91 (0.80‐1.03) | .15 | 1.05 (0.97‐1.14) | .24 | 1.02 (0.95‐1.10) | .57 |
| 22 | 0.98 (0.94‐1.02) | .29 | 1.03 (0.96‐1.11) | .40 | 0.94 (0.84‐1.04) | .23 | 0.95 (0.87‐1.03) | .22 | 0.99 (0.92‐1.06) | .76 |
Note: Model included age, gender, country and all PCs; Figure 2 and Table S8 shows name and loading of individual variables in PCs.
Abbreviations: BCL, B‐cell lymphoma; CIs, confidence intervals; CLL, chronic lymphocytic leukemia/small lymphocytic leukemia; DLBCL, diffuse large B‐cell lymphoma; FL, follicular lymphoma; HR, hazard ratios; MM, plasma cell neoplasm/multiple myeloma; PC, principal component.