Table 2.

Quantification of several phase II biotransformation enzymes

Enzyme	Median	Mean ± SD	CV	Range	n a
	pmol/mg	pmol/mg	%	(min–max)
				pmol/mg
Uridine‐5′‐diphospho (UDP)‐glucuronosyltransferase
UGT1A1	0.63	1.30 ± 1.71	131	0.14–6.49	12
UGT1A6	0.79	0.94 ± 0.59	62.9	0.30–1.72	3
UGT1A10	0.87	0.98 ± 0.60	61.6	0.37–2.46	15
UGT2A3	1.89	2.23 ± 1.60	71.6	0.64–6.92	16
UGT2B7	0.60	1.39 ± 1.82	131	0.01–5.70	14
UGT2B17	6.74	7.91 ± 6.71	84.9	1.45–29.8	16
Transferase, thioredoxin, and phosphatase enzymes
GSTA2	14.4	15.7 ± 7.49	47.9	5.27–30.6	15
GSTK1	6.55	7.23 ± 3.31	45.7	3.38–15.6	16
GSTM2	0.98	1.59 ± 1.59	100	0.38–6.76	16
GSTM4	0.24	0.74 ± 1.11	150	0.01–3.58	13
GSTO1	6.76	7.31 ± 2.98	40.7	3.25–13.8	16
GSTP1	30.6	34.6 ± 15.6	45.1	17.7–67.3	16
SULT1A2	1.49	1.69 ± 1.21	71.5	0.16–4.27	16
SULT1A3	2.99	3.04 ± 2.07	68.1	0.23–6.25	8
SULT1B1	5.47	6.25 ± 2.72	43.5	2.90–10.7	16
SULT1E1	0.21	0.29 ± 0.20	70.1	0.03–0.61	13
SULT2A1	3.95	3.95 ± 3.02	76.5	0.33–11.0	16
MGST2	4.87	5.98 ± 3.19	53.3	1.18–12.2	16
MGST3	5.40	5.69 ± 3.62	63.6	0.40–15.9	16
TXN	34.5	31.6 ± 12.2	39.0	13.9–60.3	16
ALPI	3.07	3.89 ± 3.52	90.5	0.49–13.7	16

Six UGTs (uridine‐5′‐diphospho (UDP)‐glucuronosyltransferases), six GSTs (glutathione S‐transferases), two MGSTs (microsomal glutathione S‐transferases), five SULTs (sulfotransferases), one redox enzyme (TXN, thioredoxin) and one intestinal alkaline phosphatase (ALPI) in human intestine mucosal fractions. Protein expression is represented as a median, mean ± SD (standard deviation), % CV (% coefficient of variation) and range (min–max). Abundance of enzymes is expressed in pmol/mg of intestine mucosal protein.

max, maximum; min, minimum.

^aNumber of human intestine samples.