TABLE 3.

Canonical pathway enrichment analysis for differentially expressed genes in brain regions of AD patients

Pathway	Brain region
	Cerebellum	Temporal cortex	Frontal pole (BA10)	Superior temporal gyrus (BA22)	Parahippocampal gyrus (BA36)	Inferior frontal gyrus (BA44)	DLPFC	Hippocampus
Synaptogenesis Signaling Pathway	P = 3.98 × 10‐2 Z‐score = 0.816	P = 1.15 × 10‐6 Z‐score = ‐3.051	–	P = 4.90 × 10‐4 Z‐score = ‐1.706	P = 6.17 × 10‐6 Z‐score = ‐3.606	–	P = 7.95 × 10‐1 Z‐score = 0.426	P = 3.47 × 10‐6 Z‐score = ‐5.692
Synaptic Long‐Term Depression	P = 1.85 × 10‐1 Z‐score = ND	P = 1.00 × 10‐3 Z‐score = ‐0.707	–	–	P = 1.82 × 10‐5 Z‐score = ‐1.265	–	P = 7.35 × 10‐1 Z‐score = 0.258	P = 1.20 × 10‐8 Z‐score = ‐2.770
CREB Signaling in Neurons	P = 1.32 × 10‐1 Z‐score = ND	P = 2.19 × 10‐2 Z‐score = ‐1.633	–	–	P = 8.91 × 10‐4 Z‐score = ‐1.890	–	P = 6.08 × 10‐1 Z‐score = 0	P = 5.01 × 10‐14 Z‐score = ‐2.907
Synaptic Long‐Term Potentiation	P = 1.64 × 10‐1 Z‐score = ND	P = 1.95 × 10‐2 Z‐score = ‐1.342	–	–	P = 3.02 × 10‐3 Z‐score = ‐1.633	–	P = 4.86 × 10‐1 Z‐score = ‐0.277	P = 3.89 × 10‐10 Z‐score = ‐3.212
Glutamate Receptor Signaling	P = 2.84 × 10‐1 Z‐score = ND	P = 4.68 × 10‐2 Z‐score = ND	–	–	P = 9.12 × 10‐3 Z‐score = ND	–	P = 7.95 × 10‐1 Z‐score = ND	P = 3.09 × 10‐7 Z‐score = ‐4.359

NOTE. Results are shown for the five most significantly enriched synaptic pathways among the 272 longest genes in the genome (Supplementary Table 1). Significant P‐values (P < 0.05) and Z‐scores (Z ≤ ‐2 or Z ≥ 2) are indicated in bold.

Abbreviations: AD, Alzheimer's disease; BA, Brodmann area; DLPFC, dorsolateral prefrontal cortex; ND, Not determined.