Table 4.
Statistical Analysis of Urinary Sodium/Potassium Ratio (Study 3)
| Cumulative Time Interval | Statistics | Apararenone 160 mg (n = 9) | Apararenone 640 mg (n = 9) | Eplerenone 200 mg (n = 9) | Pooled Placebo (n = 9) |
|---|---|---|---|---|---|
| 0–24 hours postdose | LS means | 0.548 | 0.925 | 0.894 | 0.508 |
| Difference (95%CI) vs placebo | 0.041 (−0.136 to 0.218) | 0.418 (0.241–0.594) | 0.387 (0.210–0.564) | — | |
| P value vs placebo | .6410 | <.0001 | .0001 | — | |
| Difference (95%CI) vs eplerenone | −0.346 (−0.504 to −0.188) | 0.031 (−0.127 to 0.189) | — | — | |
| P value vs eplerenone | .0001 | 0.6932 | — | — | |
| 24–48 hours postdose | LS means | 1.232 | 1.441 | 0.911 | 1.117 |
| Difference (95%CI) vs placebo | 0.115 (−0.065 to 0.295) | 0.324 (0.144–0.504) | −0.206 (−0.386 to −0.025) | — | |
| P value vs placebo | .2016 | .0010 | .0269 | — | |
| Difference (95%CI) vs eplerenone | 0.321 (0.159–0.482) | 0.530 (0.368–0.691) | — | — | |
| P value vs eplerenone | .0003 | <.0001 | — |
CI, confidence interval; LS, least squares.