TABLE 1.

Characteristics of NASH/NoNASH 620 Patients From the HUL Cohort

Characteristics	HL	NAFL	NASH
	n = 118	n = 431	n = 71
Biometric parameters
Women (n; %)	110; 85	300; 72	44; 60
Age (mean ± SD)	35.6 ± 11.0	35.6 ± 11.0	35.6 ± 11.0
BMI (mean ± SD)	46.2 ± 7.0	46.2 ± 7.0	46.2 ± 7.0
Body mass (kg) (mean ± SD)	128.4 ± 23.0	128.4 ± 23.0	128.4 ± 23.0
Liver histology
Steatosis grade (n; %) 0	118; 100	0; 0	0; 0
1	0; 0	310; 72	18; 25
2	0; 0	86; 20	28; 40
3	0; 0	35; 8	25; 35
Lobular inflammation (n; %) 0	118; 100	431; 100	0; 0
1	0; 0	0; 0	50; 70
2	0; 0	0; 0	21; 30
Ballooning (n; %) 0	118; 100	431; 100	0; 0
1	0; 0	0; 0	50; 70
2	0; 0	0; 0	21; 30
Fibrosis (Kleiner) (n; %) 0	107; 87	321; 74	9; 12
1a	4; 2	21; 3	9; 12
1b	2; 1	17; 1	9; 12
1c	5; 4	44; 9	4; 5
2	0; 0	13; 3	12; 16
3q	0; 0	10; 2	13; 18
3s	0; 0	4; 1	13; 18
4	0; 0	0; 0	5; 7
Liver functions
ASAT (IU/L) (median; IQR)	21; 9	23; 9	38; 23
ALAT (IU/L) (median; IQR)	20; 11	27; 16	47; 31
GGT (IU/L) (median; IQR)	25; 21	30; 27	57; 44
Metabolic parameters
Diabetes (n; %)	20; 16	145; 35	63; 86
Treated diabetes (n; %)	16; 12	121; 29	56; 77
Fasting blood glucose (mM) (mean ± SD)	5.4 ± 0.9	5.4 ± 0.9	5.4 ± 0.9
Fasting insulin (IU/mL) (median; IQR)	12.2; 8.3	13.7; 11.3	23.5; 25.8
HbA1c (%) (median; IQR)	5.5; 0.5	5.9; 0.9	7.8; 3.6
HOMA‐IR (median; IQR)	2.9; 2.2	3.5; 3.2	9.3; 10.9
Total cholesterol (mmol/L) (mean ± SD)	4.9 ± 1.0	4.9 ± 1.0	4.9 ± 1.0
LDL‐C (mmol/L) (mean ± SD)	3.1 ± 0.9	3.1 ± 0.9	3.1 ± 0.9
HDL‐C (mmol/L) (mean ± SD)	1.2 ± 0.2	1.2 ± 0.2	1.2 ± 0.2
Triglycerides (mmol/L) (mean ± SD)	1.3 ± 0.5	1.3 ± 0.5	1.3 ± 0.5
Others
Diastolic blood pressure (mm Hg) (mean ± SD)	72.6 ± 14.0	77.1 ± 14.0	76.6 ± 13.0
Systolic blood pressure (mm Hg) (mean ± SD)	130.3 ± 15.0	137.1 ± 19.0	139.2 ± 19.0

Abbreviations: GGT, gamma‐glutamyl transferase; IQR, interquartile range.