TABLE 3.
Biological Term Enrichment
|
Gene Set GO Terms |
(1,325 Genes) | (55 Genes) | (1,868 Genes) | |||
|---|---|---|---|---|---|---|
| Rank | P Value | Rank | P Value | Rank | P Value | |
| Cell‐cell adhesion | 1 | 2.9 × 10−9*** | ∅ | ∅ | 2 | 5.7 × 10−11*** |
| ATP hydrolysis‐coupled proton transport | 2 | 4.3 × 10−7*** | ∅ | ∅ | ∅ | ∅ |
| ER to Golgi vesicle‐mediated transport | 3 | 5.9 × 10−7*** | ∅ | ∅ | 130 | 1.0 × 10−2 |
| Regulation of cellular amino acid metabolic process | 4 | 6.0 × 10−7*** | ∅ | ∅ | ∅ | ∅ |
| Transferrin transport | 5 | 1.3 × 10−6** | ∅ | ∅ | ∅ | ∅ |
| Negative regulation of apoptotic process | 6 | 2.2 × 10−6** | ∅ | ∅ | 33 | 1.7 × 10−4* |
| Tumor necrosis factor–mediated signaling pathway | 7 | 2.4 × 10−6** | ∅ | ∅ | 38 | 3.5 × 10−4* |
| Regulation of macroautophagy | 8 | 3.2 × 10−6** | ∅ | ∅ | ∅ | ∅ |
| T‐cell‐receptor signaling pathway | 9 | 4.1 × 10−6** | ∅ | ∅ | 31 | 1.5 × 10−4* |
| NIK/NF‐kappa‐B signaling | 10 | 4.3 × 10−6** | ∅ | ∅ | 102 | 5.9 × 10−3 |
| G1/S transition of mitotic cell cycle | ∅ | ∅ | 1 | 1.6 × 10−4* | 17 | 1.1 × 10−5** |
| Response to organonitrogen compound | ∅ | ∅ | 2 | 6.3 × 10−4 | ∅ | ∅ |
| Cell adhesion | 50 | 1.1 × 10−3* | 3 | 1.3 × 10−3 | 5 | 4.2 × 10−8*** |
| Triglyceride catabolic process | ∅ | ∅ | 4 | 2.0 × 10−3 | ∅ | ∅ |
| Negative regulation of G1/S transition of mitotic cell cycle | ∅ | ∅ | 5 | 2.0 × 10−3 | 172 | 2.2 × 10−2 |
| Liver regeneration | 111 | 1.0 × 10−2 | 6 | 2.7 × 10−3 | 81 | 3.5 × 10−3 |
| Response to drug | 93 | 6.1 × 10−3 | 7 | 8.8 × 10−3 | 110 | 6.9 × 10−3 |
| Cellular response to hydrogen peroxide | 174 | 3.3 × 10−2 | 8 | 1.0 × 10−2 | 210 | 3.1 × 10−2 |
| Intestinal epithelial cell maturation | 161 | 2.4 × 10−2 | 9 | 1.1 × 10−2 | 241 | 4.4 × 10−2 |
| Aggresome assembly | ∅ | ∅ | 10 | 1.3 × 10−2 | ∅ | ∅ |
| Movement of cell or subcellular component | 23 | 4.0 × 10−5** | ∅ | ∅ | 1 | 3.7 × 10−11*** |
| Cell‐cell adhesion | 1 | 2.9 × 10−9*** | ∅ | ∅ | 2 | 5.7 × 10−11*** |
| Leukocyte migration | 30 | 1.4 × 10−4* | ∅ | ∅ | 3 | 1.0 × 10−10*** |
|
Fc‐gamma receptor signal (pathway in phagocytosis) |
36 | 2.4 × 10−4* | ∅ | ∅ | 4 | 5.6 × 10−9*** |
| Cell adhesion | 50 | 1.1 × 10−3* | 3 | 1.3 × 10−3 | 5 | 4.2 × 10−8*** |
| Actin cytoskeleton organization | 17 | 1.3 × 10−5** | ∅ | ∅ | 6 | 1.3 × 10−7*** |
| Leukocyte cell‐cell adhesion | 29 | 1.4 × 10−4* | ∅ | ∅ | 7 | 5.2 × 10−7*** |
| Regulation of cell shape | 86 | 5.0 × 10−3 | ∅ | ∅ | 8 | 8.1 × 10−7*** |
| Inflammatory response | 169 | 2.8 × 10−2 | ∅ | ∅ | 6 | 8.5 × 10−7*** |
| Extracellular matrix organization | 55 | 1.2 × 10−3* | ∅ | ∅ | 10 | 8.7 × 10−7*** |
Top 10 enriched GO terms for reliable DEGs in NASH vs. NoNASH men, women, and all patients subcohorts. P values and Benjamini‐Hochberg FDR were computed using DAVID and the Biological Process Direct GO terms database; enrichments were ranked following P values. Enrichments with corresponding FDR < 10%, 1%, and 0.1% are tagged with *, **, and ***, respectively.
Abbreviations: NIK, nuclear factor kappa‐B‐inducing kinase; NF‐kappa‐B, nuclear factor kappa‐B; DAVID, The Database for Annotation, Visualization and Integrated Discovery.