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Some mechanisms of vasodilation caused by TMPs and natural products. (A) Vasodilation mechanism of TMPs; (B) Vasodilation mechanism of Natural Products. The vasodilatory function of TMPs was mainly concerned with the activation of eNOs, while the natural products were primarily associated with blockage of calcium channel. They also act on other pathways, including sGC-cGMP, potassium channels, muscarinic receptors, cyclooxygenase pathways, prostaglandin I2, etc.
