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. 2020 Oct 25;35(3):1495–1507. doi: 10.1002/ptr.6915

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© 2020 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Resveratrol activated FoxO4 through phosphorylation and nuclear trans‐location. (A–D) The effect of resveratrol on FoxO4 activation was time‐ and concentration‐dependent at the protein level in AGS cells (A,B) and CDCA‐induced GIM (C, D). (E,F) Cell immunofluorescence showing the expression of FoxO4 and p‐FoxO4 Ser197 in the AGS cell line treated with or without resveratrol (incubation time: 6 hr; resveratrol dosage: 200 μM). Green: FoxO4 or p‐FoxO4 Ser197, blue: nuclei, red: cytoskeletal protein. (G,H) Cell immunofluorescence showing the expression of FoxO4 and p‐FoxO4 Ser197 in CDCA‐induced GIM with or without resveratrol treatment (incubation time: 6 hr; resveratrol dosage: 200 μM). Green: FoxO4 or p‐FoxO4 Ser197, blue: nuclei, red: cytoskeletal protein [Colour figure can be viewed at wileyonlinelibrary.com]