Figure 1.

General concept for the assembly of one‐dimensional supramolecular assemblies on a DNA origami platform. a) DNA‐functionalized and non‐functionalized monomeric building blocks co‐assemble into one‐dimensional supramolecular polymers in aqueous solution. A two‐dimensional 75×100‐nm² DNA origami platform is programmed to include single‐stranded DNA handles at specific locations, enabling hybridization to the DNA‐functionalized monomers within these aggregates. The dynamic nature of the multicomponent assembly allows for the templated exchange of various monomer derivatives. An overview of the utilized mono‐functionalized monomers, including the molecular structure of the monomer's core, is provided in the dashed inset (for reactions schemes and DNA sequences, see Figure S1). b) The rectangular DNA origami structure was designed to incorporate 15 copies of DNA‐disc 2 through DNA hybridization of ODN (a′) and the single‐stranded handles (a) protruding from the surface, following the long side of the nanostructures as indicated by the blue circles in the top view. (For clarity only 6 handles are shown here; for details on the DNA origami design, see Figure S3). AFM analysis revealed successful incorporation of DNA‐disc 2 onto DNA nanostructures as indicated by spots of high intensity at the programmed positions.