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. 2020 Nov 19;39(5):926–934. doi: 10.1097/HJH.0000000000002737

TABLE 2.

Cumulative 2-year cardiovascular death hazard ratios in comparison with quartile 2 of systolic BP in the total cohort (adjusted)a

Univariate regression Multivariate regression
Variable HR 95% CI P value HR 95%CI P value
Quartile 1 (SBP <120 mmHg) 2.22 1.68–2.94 <0.001 1.58 1.12–2.21 0.009
Quartile 3 (SBP 130–143 mmHg) 1.08 0.81–1.44 0.625 1.33 0.95–1.86 0.094
Quartile 4 (SBP at least 144 mmHg) 1.54 1.16–2.05 0.003 1.28 0.91–1.82 0.160
Sexb 0.91 0.76–1.09 0.293 0.68 0.55–0.85 0.001
Age 1.13 1.11–1.15 <0.001 3.37 1.29–8.77 0.013
Prior myocardial infraction 1.60 1.26–2.04 <0.001 1.54 1.17–2.03 0.002
Diabetes mellitus 1.25 1.05–1.50 0.015 1.08 0.84–1.37 0.560
Diagnosis of AMIc 4.50 3.73–5.42 <0.001 2.62 2.02–3.39 <0.001
Killip classd
 II 1.75 1.37–2.23 <0.001 1.82 1.38–2.40 <0.001
 III 4.64 3.49–6.16 <0.001 3.41 2.43–4.80 <0.001
 IV 21.23 15.95–28.26 <0.001 9.51 6.63–13.63 <0.001
DBP 0.99 0.98–1.00 0.007 1.00 0.99–1.01 0.785
Heart rate 1.03 1.03–1.04 <0.001 1.01 1.00–1.01 0.067
BMIe 0.90 0.88–0.92 <0.001 0.94 0.92–0.97 <0.001
Hemoglobin 0.97 0.96–0.97 <0.001 0.99 0.99–1.00 0.003
Glucose 1.11 1.09–1.13 <0.001 1.05 1.01–1.09 0.011
Albumin 0.84 0.83–0.86 <0.001 0.97 0.94–0.99 0.016
Lactate 1.11 1.06–1.15 <0.001 1.09 1.05–1.120 <0.001
eGFRf 0.96 0.96–0.97 <0.001 0.99 0.98–0.99 <0.001
hs-CRP 1.05 1.04–1.06 <0.001 1.01 1.00–1.02 0.072

AMI, acute myocardial infarction; CI, confidence interval; eGFR, estimated glomerular filtration rate; HR, hazard ratio; hsCRP, high-sensitivity C-reactive protein; SP, blood pressure.

a

Adjusted for age; sex; concomitant diseases; diagnosis of AMI; Killip class grade; cardiac shock at admission; DBP; heart rate; BMI; hemoglobin; glucose; albumin; lactate; eGFR; and hsCRP. Quartile 2 had a SBP of 120–129 mmHg. n = 5696 with data on all covariates.

b

Sex was set as 1 for men, 2 for women, in the statistical analysis.

c

Diagnosis of AMI was set as 0 for unstable angina, 1 for AMI.

d

Degree of heart failure present on admission categorized by Killip class; P values were for comparisons with group of Killip class I.

e

Calculated as weight in kilograms divided by height in meters squared.

f

Calculated with Chronic Kidney Disease Epidemiology (CKD-EPI) equation.