Search	Query	Items identified
#10	#9 AND [english]/lim	3,547
#9	#7 NOT #8	3,685
#8	(rat:ti OR rats:ti OR mouse:ti OR mice:ti OR swine:ti OR porcine:ti OR murine:ti OR sheep:ti OR lambs:ti OR pigs:ti OR piglets:ti OR rabbit:ti OR rabbits:ti OR cat:ti OR cats:ti OR dog:ti OR dogs:ti OR cattle:ti OR bovine:ti OR monkey:ti OR monkeys:ti OR trout:ti OR marmoset*:ti) AND ’animal experiment’/de	1,062,853
#7	#5 NOT #6	3,690
#6	‘animal experiment’/de NOT (‘human experiment’/de OR ’human’/de)	2,247,064
#5	#3 AND #4	3,943
#4	‘clinical trial’/exp OR ’randomization’/exp OR randomized:ti,ab OR randomised:ti,ab OR placebo:ti,ab OR randomly:ti,ab OR trial:ti,ab OR groups:ti,ab OR ’clinical trial (topic)’/exp OR ’double blind procedure’/exp OR 'single blind procedure’/exp OR ’triple blind procedure’/exp OR (((singl* OR doubl* OR trebl* OR tripl*) NEAR/10 (mask* OR blind* OR dumm*)):ti,ab) OR ’crossover procedure’/exp OR (((crossoverOR ’cross over’) NEAR/10 (study OR studies OR design* OR method* OR procedure OR comparison)):ti,ab) OR ’meta analysis’/exp OR ’meta analysis (topic)’/exp OR 'systematic review’/exp OR 'systematic review (topic)’/exp OR ’biomedical technology assessment’/exp OR ((systematic* NEAR/3 (review* OR overview*)):ti,ab) OR ((methodologic* NEAR/3 (review* OR overview*)):ti,ab) OR ((quantitative NEAR/3 (review* OR overview* OR synthes*)):ti,ab) OR ((research NEAR/3 (integrati* OR overview*)):ti,ab) OR ((integrative NEAR/3 (review* OR overview*)):ti,ab) OR ((collaborative NEAR/3 (review* OR overview*)):ti,ab) OR ((pool* NEAR/3 analy*):ti,ab) OR ((data NEAR/1 (synthes* OR extraction* OR abstraction*)):ti,ab) OR handsearch*:ti,ab OR ’hand search’:ti,ab OR ’hand searches’:ti,ab OR ’hand searching’:ti,ab OR ’mantel haenszel’:ti,ab OR peto:ti,ab OR ’der simonian’:ti,ab OR dersimonian:ti,ab OR ’fixed effect’:ti,ab OR ’fixed effects’:ti,ab OR ’latin square’:ti,ab OR ’latin squares’:ti,ab OR ’meta analysis’:ti,ab OR ’meta analyses’:ti,ab OR ’met analysis’:ti,ab OR ’met analyses’:ti,ab OR metaanaly*:ti,ab OR metanaly*:ti,ab OR ’meta regression’:ti,ab OR ’meta regressions’:ti,ab OR metaregression*:ti,ab OR medline:ti,ab OR cochrane:ti,ab OR pubmed:ti,ab OR medlars:ti,ab OR embase:ti,ab OR cinahl:ti,ab OR cochrane:jt OR ’evidence report’:it OR ((comparativeNEAR/3 (efficacy OR effectiveness)):ti,ab) OR ’outcomes research’:ti,ab OR ’relative effectiveness’:ti,ab OR (((indirect OR ’indirect treatment’ OR ’mixed treatment’) NEAR/3 comparison):ti,ab)	5,425,604
#3	#1 AND #2	7,629
#2	‘body weight loss’/exp OR (((weight OR fat OR ’adipose tissue’) NEAR/3 (decreas* OR loss OR losing OR reduc*)):ti,ab,kw) OR ((weightNEAR/3 management):ti,ab,kw) OR ((chang* NEAR/3 (‘adipose tissue’ OR ’fat mass’ OR ’fat tissue’ OR weight)):ti,ab,kw)	332,351
#1	‘low calorie diet’/exp/mj OR ’very low calorie diet’/exp/mj OR ’elimination diet’/exp/mj OR ’liquid diet’/exp/mj OR ((low NEAR/3 (calori* OR energy OR elimination) NEAR/5 (diet OR diets)):ti,ab,kw) OR vlcd:ti,ab,kw OR vled:ti,ab,kw OR lcd:ti,ab,kw OR (((ketogenic OR replacementOR ’meal substitute’ OR liquid) NEAR/5 (diet OR diets)):ti,ab,kw) OR ’reducing diet’:ti,ab,kw OR ’reducing diets’:ti,ab,kw OR (((calori* OR energ*) NEAR/3 (reduc* OR restrict*) NEAR/5 (diet OR diets)):ti,ab,kw)	25,963