Search	Query	Items identified
#24	#14 AND #22 AND [english]/lim	5,340
#23	#14 AND #22	5,792
#22	#15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21	5,441,679
#21	((data NEAR/1 (synthes* OR extraction* OR abstraction*)):ti,ab) OR handsearch*:ti,ab OR ’hand search’:ti,ab OR ’hand searches’:ti,ab OR ’hand searching’:ti,ab OR ’mantel haenszel’:ti,ab OR peto:ti,ab OR ’der simonian’:ti,ab OR dersimonian:ti,ab OR ’fixed effect’:ti,ab OR ’fixed effects’:ti,ab OR ’latin square’:ti,ab OR ’latin squares’:ti,ab OR ’meta analysis’:ti,ab OR ’meta analyses’:ti,ab OR ’met analysis’:ti,ab OR ’met analyses’:ti,ab OR metaanaly*:ti,ab OR metanaly*:ti,ab OR ’meta regression’:ti,ab OR ’meta regressions’:ti,ab OR metaregression*:ti,ab OR medline:ti,ab OR cochrane:ti,ab OR pubmed:ti,ab OR medlars:ti,ab OR embase:ti,ab OR cinahl:ti,ab OR cochrane:jt OR ’evidence report’:jt OR ((comparative NEAR/3 (efficacy OR effectiveness)):ti,ab) OR ’outcomes research’:ti,ab OR ’relative effectiveness’:ti,ab OR (((indirect OR ’indirect treatment’ OR ’mixed treatment’) NEAR/3 comparison):ti,ab)	457,245
#20	((systematic* NEAR/3 (review* OR overview*)):ti,ab) OR ((methodologic* NEAR/3 (review* OR overview*)):ti,ab) OR ((quantitative NEAR/3 (review* OR overview* OR synthes*)):ti,ab) OR ((research NEAR/3 (integrati* OR overview*)):ti,ab) OR ((integrative NEAR/3 (review* OR overview*)):ti,ab) OR ((collaborative NEAR/3 (review* OR overview*)):ti,ab) OR ((pool* NEAR/3 analy*):ti,ab)	273,287
#19	‘meta analysis’/exp OR ’meta analysis (topic)’/exp OR 'systematic review’/exp OR 'systematic review (topic)’/exp OR ’biomedical technology assessment’/exp	402,087
#18	‘crossover procedure’/exp OR (((crossover OR ’cross over’) NEAR/10 (study OR studies OR design* OR method* OR procedure OR comparison)):ti,ab)	93,442
#17	((singl* OR doubl* OR trebl* OR tripl*) NEAR/10 (mask* OR blind* OR dumm*)):ti,ab	249,335
#16	‘clinical trial (topic)’/exp OR ’double blind procedure’/exp OR 'single blind procedure’/exp OR ’triple blind procedure’/exp	532,591
#15	‘clinical trial’/exp OR ’randomization’/exp OR randomized:ti,ab OR randomised:ti,ab OR placebo:ti,ab OR randomly:ti,ab OR trial:ti,ab OR groups:ti,ab OR (group1:ti,ab AND group 2:ti,ab)	4,864,364
#14	#12 NOT #13	16,546
#13	(rat:ti OR rats:ti OR mouse:ti OR mice:ti OR swine:ti OR porcine:ti OR murine:ti OR sheep:ti OR lambs:ti OR pigs:ti OR piglets:ti OR rabbit:ti OR rabbits:ti OR cat:ti OR cats:ti OR dog:ti OR dogs:ti OR cattle:ti OR bovine:ti OR monkey:ti OR monkeys:ti OR trout:ti OR marmoset*:ti) AND ’animal experiment’/de	1,064,998
#12	#10 NOT #11	16,569
#11	‘animal experiment’/de NOT (‘human experiment’/de OR ’human’/de)	2,250,526
#10	#3 OR #6 OR #8 OR #9	18,100
#9	(‘magnesium’/exp OR ’magnesium salt’/exp OR magnesium:ti,ab,kw) AND (‘dietary supplement’/exp OR ’fortified food’/exp OR ’diet’/de) OR ((magnesium NEAR/3 (intak* OR supplement* OR therap* OR diet*;ti,ab,kw)):ti,ab,kw) OR ’mg supplement*’:ti,ab,kw OR ’mg fortified’:ti,ab,kw OR ’magnesium intake’/exp OR ’magnesium’/mj/dd_dt OR ’magnesium salt’/mj/dd_dt	9,906
#8	#6 OR #7	6,767
#7	‘magnesium’/exp/dd_ae,dd_to OR ’magnesium salt’/exp/dd_ae,dd_to	1,092
#6	#4 AND #5	5,886
#5	‘adverse event’/de OR ’adverse drug reaction’/exp OR ’intoxication’/de OR ’drug intoxication’/exp OR ’drug overdose’/exp OR ’toxicity’/exp OR ’contraindication’/exp OR ’risk’/de OR ’risk factor’/exp OR ’risk assessment’/exp OR 'safety’/de OR ’patient safety’/exp OR ’food safety’/exp OR ’drug safety’/exp OR adverse:ti,ab,kw OR (((undesirable OR harm* OR serious OR negative OR side OR unwanted OR untoward) NEAR/5 (effect* OR reaction* OR event* OR interaction* OR outcome* OR response* OR sequala* OR sequela*)):ti,ab,kw) OR intoxic*:ti,ab,kw OR toxic*:ti,ab,kw OR overdose*:ti,ab,kw OR ((risk* NEAR/5 (assessment* OR factor*)):ti,ab,kw) OR contraindication*:ti,ab,kw OR ’contra indication’:ti,ab,kw OR ’contra indications’:ti,ab,kw OR safe:ti,ab,kw OR safety:ti,ab,kw	5,724,197
#4	‘magnesium’/exp/mj OR ’magnesium salt’/exp/mj OR ’magnesium intake’/exp/mj OR magnesium:ti	44,385
#3	#1 AND #2	4,041
#2	‘tolerability’/exp OR ’diarrhea’/exp OR diarrhe*:ti,ab,kw OR diarrhoe*:ti,ab,kw OR dysenter*:ti,ab,kw OR ’feces’/exp OR feces:ti,ab,kw OR faec*:ti,ab,kw OR fecal:ti,ab,kw OR laxative:ti,ab,kw OR stool:ti,ab,kw OR stools:ti,ab,kw OR tolerab*:ti,ab,kw OR ((osmotic NEAR/3 (effect OR effects)):ti,ab,kw)	636,059
#1	‘magnesium’/exp OR ’magnesium intake’/exp OR ’magnesium salt’/exp OR magnesium:ti,ab,kw	127,141