Table 2.
Characteristics of sporadic colorectal lesions
| HP (n = 25) | SSL (n = 35) | TSA (n = 38) | |
|---|---|---|---|
| Proximal location | 19 (76%) | 30 (85.7%) | 9 (23.7%) |
| Dysplasia | – | 2 (5.7%) | 38 (100%) |
| CRC in polyp | – | – | 1 (2.6%) |
| MSS* | 24 (96.0%) | 31 (86.6%) | 33 (81.6%) |
| RNF43 | – | 1 × p.Arg40Lysfs | 1 × p.Gly67Asp |
| MSI* | 1 (4.0%) | 4 (4.1%) | 5 (5.1%) |
| RNF43 | – | – |
1 × p.Arg117fs† 1 × p.Gly659fs + p.Glu318Ter† |
HP, Hyperplastic polyp; SSL, Sessile serrated lesion; TSA, Traditional serrated adenoma; CRC, Colorectal carcinoma; MSI, Microsatellite‐instable; MSS, Microsatellite‐stable; MMR, Mismatch repair.
*
Immunohistochemistry for MMR genes normal staining pattern and normal pentaplex.
†
Although cases were randomly selected based on histological diagnosis, these polyps turned out to be from known Lynch syndrome patients.