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. 2020 Nov 26;53(5):1672–1686. doi: 10.1111/ejn.15041

Figure 6.

Figure 6

Stronger response to 14‐Hz stimulation in the frequency‐shifted paradigm in familial hemiplegic migraine type 1 (FHM1) mutant compared to wild‐type (WT) mice. (a) Top: Frequency‐shifted stimulation paradigm consisting of alternating blocks of 24 flashes at 8 Hz (duration: 3 s) and blocks of 42 flashes at 14 Hz (duration: 3 s). Bottom: Example trace of the averaged EEG response to the frequency‐shifted stimulation paradigm. (b) Top: Normalized EEG power at 8 Hz in response to the frequency‐shifted paradigm shows a similar response and rest pattern in WT and mutant mice. Bottom: Normalized EEG power at 14 Hz shows increased response to 14 Hz stimulation in mutant mice compared to WT (significance indicated: **p = .005)