Figure 3.

Isoniazid exposures stratified by NAT2 genotype and pregnancy. The box plot (with box representing median and interquartile range and whiskers the 5th‐95th interval) summarizes isoniazid maximum concentration (C_max) on the right and 0–24‐hour area under the concentration‐time curve (AUC_0–24) on the left for the three genotypes (slow, intermediate, and rapid acetylator) for both the antepartum (red solid line) and postpartum (blue dashed lines) visit. AUC_0–24 was calculated by integrating between the 0 and 24 hours after dosing time points. The inset panel shows the same values on the log‐scale. [Colour figure can be viewed at wileyonlinelibrary.com]