Figure 4.

Efavirenz exposures stratified by CYP2B6 genotype, pregnancy and isoniazid co‐administration. (a, b) Displays box plot (with box representing median and interquartile range and whiskers the 5th‐95th interval) summarizing 0–24‐hour area under the concentration‐time curve (AUC_0–24) and concentrations at 12 hours postdosing (C₁₂), respectively, for the three genotypes (slow, intermediate, and normal metabolizer) stratified by pregnancy (solid line) and postpartum (dashed lines) visit. (c, d) Stratify AUC_0‐24 and C₁₂, respectively, using INH co‐administration. [Colour figure can be viewed at wileyonlinelibrary.com]