Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Synthetic routes for CRBN‐building blocks. Reagents and conditions: a) sodium acetate, acetic acid, overnight reflux, yield 90 %; b) H2, Pd/C, RT, 24 h, yield 92 %; c) potassium acetate, acetic acid, reflux 3 h, yield 32 %; d) THF, reflux, 30 min, yield 92 %; e) sodium iodide, potassium carbonate, THF, RT, yield 81 %; f) sodium acetate, acetic acid, overnight reflux, yield 85 %; g) N‐Boc‐propane‐1,3‐diamine or N‐Boc‐butane‐1,4‐diamine, DIPEA, DMF, overnight reflux, yield 60 %.
