FIGURE 2.

DNA methylation pattern of six methylation markers (GHSR, SST, ZIC1, ASCL1, LHX8 and ZNF582) across all four histological disease categories. Predicted probabilities (pp) per sample (column) are colored from green (pp of 0, ie, low) to red (pp of 1, ie, high). In each disease category, samples are ordered based on their average pp (Avg pp). HPV status of the samples and age of the patients is displayed at the bottom of each disease category. +, HPV positive; −, HPV negative; VIN, high‐grade vulvar intraepithelial neoplasia; VSCC, vulvar squamous cell carcinoma [Color figure can be viewed at wileyonlinelibrary.com]