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Targeting protein–protein interactions (PPIs). a) The interaction of transcription factor TEAD and the transcriptional co‐activator YAP is an exemplary protein–protein interaction. b) Classification of peptide‐derived and ‐inspired modalities for targeting PPIs. c) Design strategies for the identification of PPI inhibitors. d) Selection of DNA‐encoded libraries enables scanning protein surface with numerically large compound libraries.
