TABLE 1.

DPPs and two related exopeptidases expressed in P. gingivalis

Name	IUBMB	MEROPS code	Gene code a	Specificity b	Synthetic and native substrate	Isozyme	Reference
DPP3	EC3.4.14.4	M49.001	PGN_01645	NH2‐RR‐|‐	RR‐NHMec		Ellis & Nuenke (1967); Ohara‐Nemoto et al. (2014)
DPP4	EC3.4.14.5	S9.013	PGN_1469	NH2‐XP‐|‐ NH2‐XA‐|‐	GP‐MCA Incretin	FAPα/seprase DPP6/DPPX DPP8/DPRP1 DPP9/DPRP2 DPP10/DPRP3 DPP‐A and B	Banbula et al. (2000); Ohara‐Nemoto et al. (2017)
DPP5		S9.012	PGN_0756	NH2‐AA‐|‐ NH2‐HS‐|‐ NH2‐SY‐|‐	KA‐MCA		Ohara‐Nemoto et al. (2014)
DPP6		C40.001	PGN_0754	L‐Ala‐γ‐D‐Glu‐|‐			Guinand et al. (1979)
DPP7		S46.001	PGN_1479	NH2‐AF‐|‐ NH2‐ZZ‐|‐	FM‐MCA		Banbula et al. (2001); Rouf, et al. (2013); Nemoto et al. (2018)
DPP11		S46.002	PGN_0607	NH2‐ZD‐|‐ NH2‐ZE‐|‐	LD‐MCA LE‐MCA		Ohara‐Nemoto et al. (2011); Rouf, et al. (2013); Nemoto et al. (2017)
AOP		S9C	PGN_1349	Acyl‐ZZ‐|‐ Acyl‐XZZ‐|‐	Benzyloxycarbonyl‐KM‐MCA		Nemoto et al. (2016); Nemoto et al. (2019)
PTP‐A	EC3.4.14.12	S9.017	PGN_1149	NH2‐XXP‐|‐	GAP‐β‐naphthylamide		Banbula et al. (1999); Ito et al. (2006)

^a P. gingivalis ATCC 33277 (Naito et al., 2008).

^bX, any amino acid, Z, hydrophobic amino acid, “‐|‐”, cleavage site