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. 2020 Nov 30;22(6):1012–1019. doi: 10.1002/cbic.202000574

Figure 2.

Figure 2

CXCR2 binding and inhibition properties of MIF(47–56) peptide analogues. A) Comparison of the binding capacity of MIF(47–56) and its Ala variants MIF(47–56/L47A) and MIF(47–56/M48A) (each applied at a concen‐tration of 500 μM) to CXCR2, as measured by DMR technology using HEK‐CXCR2 transfectants. B) Inhibitory capacity of MIF(47–56) and its Ala variants (5 μM) on monocyte chemotaxis elicited by human MIF (8 nM), as analyzed by a Transwell‐based assay device (n=3–11, mean±SD). Statistical significance is indicated: * P<0.05, ** P<0.01, *** P<0.001, ns=not significant.