Figure 8.

Comparison of the drug responses in PDSs seeded with three different cell lines. Radar charts represent the average modulation of genes related to CSC, proliferation, EMT, and differentiation following treatment with (a) DOX and (b) 5‐FU at the concentration 50X. Data represent relative quantities to untreated PDSs cultured with the specific cell line (MCF7, MDA‐MB‐231, or T‐47D) in log2 scale (n = 3). The genes used for the average calculation were chosen based on their relevance in the drug response for every model and are detailed in Table S3. 5‐FU, 5‐fluorouracil; CSC, cancer stem cell; DOX, doxorubicin; EMT, epithelial–mesenchymal transition; PDS, patient‐derived scaffold