Table 1.

Hit compounds from the DSF screen causing a thermal shift for more than one target. DSF/ΔT _m is reported in mean [°C].

	sEH	LTA4H	5‐LOX	RXRα	FXR
1	0.0±0.0	−0.5±0.0	0.9±0.0	1.1±0.0	−0.1±0.0
2	2.2±0.0	−0.1±2.1	1.1±0.0	−9.5±24.0	0.3±0.0
3	0.0±0.0	2.5±0.0	−1.1±0.0	−2.9±0.0	1.4±0.7
4	0.0±0.0	1.5±0.0	−1.1±0.0	−2.4±0.7	5.4±0.7
5	0.0±0.0	1.7±0.0	−0.1±0.0	0.8±0.7	1.2±0.0
6	2.0±0.0	1.4±1.4	−1.4±2.1	−1.0±0.7	−1.2±0.7
7	1.0±0.0	0.5±0.0	0.9±0.0	−0.4±0.7	−0.6±0.7
8	0.0±0.0	1.5±0.0	−0.1±0.0	0.1±0.0	1.9±0.0
9	1.0±0.0	0.7±0.0	−1.1±0.0	2.3±0.0	21.7±3.5 [a]
10	0.6±0.7	2.4±0.0	0.9±0.0	1.9±0.0	−11.6±2.1

[a] The melting curve is shown in the Supporting Information