Table 3.
Bronchoalveolar lavage fluid (BALF) and peripheral blood cellularity in patients with severe/critical COVID-19
| Total patients | Patients with ARDSa/critical pulmonary infection (IMVb) |
Peripheral blood cellularity | BALF cellularity or lung biopsy | |
|---|---|---|---|---|
| Wu C et al. JAMA Int Med 2020 [13] | 201 |
84 (N = 6, 2.9%) |
>Neutrophils < TCD4+ and TCD8+ |
No data |
| Chen T et al. BMJ 2020 [12] | 274 |
196 (N = 17, 6.2%) |
< Lymphocytes >Neutrophils |
No data |
| Chen G et al. J Clin Invest 2020 [21] | 21 |
11 (N = 0) |
< Lymphocytes >Neutrophils |
No data |
| Tang X et al. Chest 2020 [23] | 73 |
36 (N = 14, 19.2%) |
< Lymphocytes (TCD4+ and TCD8+) | No data |
| Liao M et al. Nature Medicine 2020 [7] | 9 |
6 (n.a.c) |
No data |
>Macrophages >Neutrophils < T and NK Lymphocytes |
| Xu Z et al. Lancet Resp Med 2020 [14] | 1 |
1 (N = 1, 100%) |
< TCD4+ and TCD8+ Activated Lymphocytes (HLA-DR+) |
>Lymphocytes |
| Tian S et al. Mod Pathol 2020 [8] | 4 |
4 (n.a.) |
< Lymphocytes | >Mononuclear cells |
| Carsana L et al. Lancet Infect Dis 2020 [24] | 38 |
38 (n.a.) |
No data |
>Macrophages >Lymphocytes |
aARDS Acute Respiratory Distress Syndrome, bIMV Invasive mechanical ventilation, cn.a. not available