Table I.
Demographics and clinical characteristics of melanoma patients from the Surveillance, Epidemiology, and End Results registry
| Characteristics | NHW | Hispanic | NHB | NHAPI | NHAIAN | P value* |
|---|---|---|---|---|---|---|
| N (%) | 379,736 (95.40) | 12,290 (3.09) | 2286 (0.57) | 2913 (0.73) | 809 (0.20) | |
| Age at diagnosis, y, mean (SD) | 60.25 (16.97) | 55.08 (18.08) | 61.87 (17.70) | 59.02 (18.48) | 55.55 (17.22) | <.001 |
| Male gender, n (%) | 218,849 (57.6) | 5223 (42.5) | 1035 (45.3) | 1385 (47.5) | 414 (51.2) | <.001 |
| Year of diagnosis, n (%) | <.001 | |||||
| <2000 | 82,126 (21.6) | 2113 (17.2) | 584 (25.5) | 647 (22.2) | 139 (17.2) | |
| 2000–2009 | 156,649 (41.3) | 5113 (41.6) | 915 (40.0) | 1192 (40.9) | 323 (39.9) | |
| ≥2010 | 140,961 (37.1) | 5064 (41.2) | 787 (34.4) | 1074 (36.9) | 347 (42.9) | |
| Primary site, n (%) | <.001 | |||||
| Skin of trunk | 119,928 (31.6) | 2932 (23.9) | 298 (13.0) | 565 (19.4) | 218 (26.9) | |
| External ear | 10,874 (2.9) | 294 (2.4) | 14 (0.6) | 40 (1.4) | 25 (3.1) | |
| Unspecified parts of the face | 34,906 (9.2) | 1074 (8.7) | 89 (3.9) | 133 (4.6) | 71 (8.8) | |
| Skin of the scalp and neck | 28,466 (7.5) | 645 (5.2) | 95 (4.2) | 109 (3.7) | 55 (6.8) | |
| Skin of the upper limb and shoulder | 90,130 (23.7) | 2333 (19.0) | 262 (11.5) | 444 (15.2) | 161 (19.9) | |
| Skin of the lower limb and hip | 63,176 (16.6) | 3181 (25.9) | 961 (42.0) | 914 (31.4) | 162 (20.0) | |
| Other skin | 17,142 (4.5) | 806 (6.6) | 231 (10.1) | 240 (8.2) | 61 (7.5) | |
| Mucosal | 3569 (0.9) | 441 (3.6) | 232 (10.1) | 327 (11.2) | 23 (2.8) | |
| Uveal | 11,545 (3.0) | 584 (4.8) | 104 (4.5) | 141 (4.8) | 33 (4.1) | |
| Histologic subtype, n (%) | <.001 | |||||
| Superficial spreading melanoma | 118,737 (31.3) | 3150 (25.6) | 295 (12.9) | 549 (18.8) | 228 (28.2) | |
| Malignant melanoma, NOS | 187,137 (49.3) | 6510 (53.0) | 1308 (57.2) | 1595 (54.8) | 420 (51.9) | |
| Nodular melanoma | 26,858 (7.1) | 1061 (8.6) | 188 (8.2) | 241 (8.3) | 60 (7.4) | |
| Lentigo maligna melanoma | 25,497 (6.7) | 421 (3.4) | 54 (2.4) | 95 (3.3) | 29 (3.6) | |
| Acral lentiginous melanoma | 2551 (0.7) | 495 (4.0) | 303 (13.3) | 250 (8.6) | 23 (2.8) | |
| Desmoplastic melanoma | 4008 (1.1) | 95 (0.8) | 26 (1.1) | 32 (1.1) | 9 (1.1) | |
| Spindle cell melanoma, NOS | 4999 (1.3) | 167 (1.4) | 38 (1.7) | 44 (1.5) | 11 (1.4) | |
| Other | 9949 (2.6) | 391 (3.2) | 74 (3.2) | 107 (3.7) | 29 (3.6) | |
| Stage, n (%) | <.001 | |||||
| Localized | 292,655 (77.1) | 8174 (66.5) | 1169 (51.1) | 1707 (58.6) | 560 (69.2) | |
| Regional | 33,522 (8.8) | 1744 (14.2) | 468 (20.5) | 531 (18.2) | 104 (12.9) | |
| Distant | 14,277 (3.8) | 840 (6.8) | 310 (13.6) | 304 (10.4) | 46 (5.7) | |
| Unstaged | 39,282 (10.3) | 1532 (12.5) | 339 (14.8) | 371 (12.7) | 99 (12.2) | |
| Skin thickness, mm, mean (SD) | 1.22 (1.70) | 1.69 (2.20) | 2.80 (2.84) | 2.13 (2.52) | 1.49 (1.96) | <.001 |
| Skin thickness and localized stage, mm, mean (SD) | 0.93 (1.21) | 1.11 (1.41) | 1.74 (1.95) | 1.34 (1.60) | 1.06 (1.29) | <.001 |
| Skin ulceration, n (%) | 27,288 (12.8) | 1330 (19.6) | 354 (37.3) | 307 (23.0) | 73 (16.2) | <.001 |
| Skin ulceration and localized stage, n (%) | 16,184 (9.5) | 591 (12.2) | 151 (26.6) | 137 (14.8) | 36 (10.8) | <.001 |
| Follow-up, mo, median (IQR) | 86 (34–155) | 71 (24–141) | 77 (26–152) | 76 (26–153) | 74 (27–150) | <.001 |
IQR, Interquartile range; NHAIAN, non-Hispanic American Indian/Alaska Native; NHAPI, non-Hispanic Asian or Pacific Islander; NHB, non-Hispanic black; NHW, non-Hispanic white; NOS, not otherwise specified; SD, standard deviation.
*
Estimated by analysis of variance for continuous variables and chi-squared tests for categorical variables to compare clinical and demographic characteristics among the racial groups.