Supplemental Table 1. Definitions of CVD events in the DREAM cohort.

CVD event	Definition
Ischemic heart disease (IHD)	IHD included myocardial infarction, percutaneous coronary intervention, and coronary artery bypass grafting. Angina pectoris was included in IHD only when myocardial ischemia was evident by electrocardiogram and/or stress myocardial scintigraphy.
Stroke	Stroke denoted symptomatic stroke with sudden onset of neurological deficit confirmed by magnetic resonance imaging (MRI) and/or X-ray computed tomography (CT) of the brain. Based on available information, stroke were classified into ischemic stroke, hemorrhagic stroke, and unspecified. Transient ischemic attack was not included in stroke.
Peripher alartery disease (PAD)	PAD was diagnosed when the patient had history of amputation of lower limb, percutaneous transluminal angioplasty, and/or bypass grafting due to ischemic limb. We did not include intermittent claudication, leg pain at rest, or foot ulceration in PAD if none of the above mentioned treatment was performed.
Congestive heart failure (CHF)	CHF was defined by severe pulmonary edema requiring hospitalization, excluding pneumonia, but not excluding non-cardiac circulatory failure.
Valve disease	Valve disease was diagnosed when the patienthad valve replacement.

Sudden deaths are considered as fatal CVD events.

Abbreviations: IHD, ischemic heart disease; MRI, magnetic resonance imaging; CT, computed tomography; PAD, peripher alartery disease; CHF, congestive heart failure.