Table 3.
Diagnostic performance of LSM for fibrosis F ≥ F2, F ≥ F3, and F = F4
| F ≥ F2 | F ≥ F3 | F = F4 | |
| AUROC (95% CI) | 0.71 (0.63–0.80) | 0.71 (0.62–0.80) | 0.77 (0.58–0.97) |
| Prevalence (N) | 0.61 (85/140) | 0.36/(50/140) | 0.04 (5/140) |
| Youden index | |||
| Cutoff (kPa) | 9.4 | 9.4 | 11 |
| Se (95% CI) | 0.58 (0.47–0.68) | 0.68 (0.55–0.81) | 0.80 (0.45–1.00) |
| TP/(TP + FN) | 49/(49 + 36) | 34/(34 + 16) | 4/(4 + 1) |
| Sp (95% CI) | 0.82 (0.72–0.92) | 0.72 (0.63–0.81) | 0.71 (0.63–0.79) |
| TN/(TN + FP) | 45/(45 + 10) | 65/(65 + 25) | 96/(96 + 39) |
| PPV (95% CI) | 0.83 (0.73–0.93) | 0.58 (0.45–0.70) | 0.09 (0.006–0.18) |
| NPV (95% CI) | 0.56 (0.45–0.66) | 0.80 (0.72–0.89) | 0.99 (0.97–1.00) |
| LR+ (95% CI) | 3.17 (1.76–5.72) | 2.45 (1.67–3.59) | 2.77 (1.66–4.62) |
| LR− (95% CI) | 0.52 (0.39–0.68) | 0.44 (0.29–0.68) | 0.28 (0.05–1.63) |
| Se = 0.90 | |||
| Cutoff (kPa) | 5.3 | 6.1 | 11 |
| Se (95% CI) | 0.92 (0.86–0.98) | 0.88 (0.79–0.97) | 0.80 (0.45–1.00) |
| TP/(TP + FN) | 78/(78 + 7) | 44/(44 + 6) | 4/(4 + 1) |
| Sp (95% CI) | 0.22 (0.11–0.33) | 0.27 (0.18–0.36) | 0.71 (0.63–0.79) |
| TN/(TN + FP) | 12/(12 + 43) | 24/(24 + 66) | 96/(96 + 39) |
| PPV (95% CI) | 0.64 (0.56–0.73) | 0.40 (0.31–0.49) | 0.09 (0.006–0.18) |
| NPV (95% CI) | 0.71 (0.49–0.92) | 0.80 (0.66–0.94) | 0.99 (0.97–1.00) |
| LR+ (95% CI) | 1.17 (1.01–1.37) | 1.20 (1.02–1.41) | 2.77 (1.66–4.62) |
| LR− (95% CI) | 0.38 (0.16–0.90) | 0.45 (0.20–1.03) | 0.28 (0.05–1.63) |
| Sp = 0.90 | |||
| Cutoff (kPa) | 13.3 | 15 | 21.4 |
| Se (95% CI) | 0.34 (0.24–0.44) | 0.40 (0.26–0.54) | 0.40 (0.03–0.83) |
| TP/(TP + FN) | 29/(29 + 56) | 20/(20 + 30) | 2/(2 + 3) |
| Sp (95% CI) | 0.91 (0.83–0.99) | 0.90 (0.84–0.96) | 0.90 (0.85–0.85) |
| TN/(TN + FP) | 50/(50 + 5) | 81/(81 + 9) | 122/(122 + 13) |
| PPV (95% CI) | 0.85 (0.73–0.97) | 0.69 (0.52–0.86) | 0.13 (0.04–0.31) |
| NPV (95% CI) | 0.47 (0.38–0.57) | 0.73 (0.65–0.81) | 0.98 (0.95–1.00) |
| LR+ (95% CI) | 3.75 (1.55–9.11) | 4.00 (1.97–8.11) | 4.15 (1.26–13.67) |
| LR− (95% CI) | 0.72 (0.61–0.86) | 0.67 (0.53–0.84) | 0.66 (0.32–1.36) |
AUROC, area under the receiver operating characteristic curve; CI, confidence interval; FP, false positive; FN, false negative; LR+, positive likelihood ratio; LR−, negative likelihood ratio; LSM, liver stiffness measurement; NPV, negative predictive value; PPV, positive predictive value; Se, sensitivity; Sp, specificity; TP, true positive; TN, true negative.