Table 1.

Crohn's disease transmural histopathological score (23)

Score	Grade	Features	Score
Inflammation	Mild	Aphthous ulcers affected surface <50%; cryptitis <50%; inflammation limited to mucosa	1
	Moderate	Large, superficial ulcers (0.5–2 cm) Ulcerated surface <50%; affected surface 50%–100% Cryptitis >50%; crypt abscesses; submucosal inflammation	2
	Severe	Deepa ulcers or ulcers >2 cm in size; circumferential ulcers; deepa fissures; transmural inflammation	3
Fibrosis	None	None or minimal fibrosis limited to submucosa (<25% thickness)	0
	Mild/moderate	Mild stricture (>15 mm) with nondilated lumen Submucosal fibrosis and muscular hyperplasia >25%b with preserved layers	1
	Severe	Massive transmural fibrosis; effacement of normal layers; severe stricture	2

^aDeep—beyond the submucosa.

^bIncludes muscular propria hyperplasia >25%, muscularis mucosae hyperplasia >25%, and/or splayed muscularis mucosae (without cellular hyperplasia) >25%.