Table 3.
Postoperative outcomes variables, per phenotype
| Total (n = 103) | B2 (n = 29, 28%) | B3 (n = 74, 72%) | Pa | |
| Reoperation, n (%) | 10 (10) | 3 (10) | 7 (10) | >0.999a |
| Time from index to subsequent surgery, yr, median (P25–P75)b | 6.7 (1.8–10.4) | 6.0 (1.2–7.5) | 7.8 (2.0–11.5) | 0.425c |
| Hospitalization, n (%) | 30 (29) | 10 (35) | 20 (27) | 0.454a |
| Time from index to subsequent hospitalization, yr, median (P25–P75)b | 2.0 (0.8–3.5) | 7.8 (1.2–3.0) | 2.0 (0.7–4.2) | 0.947c |
| Steroids, n (%) | 32 (31) | 14 (48) | 18 (24) | 0.018a |
| No. of postoperative steroid courses, median (min–max) | 1 (1–2) | 1 (1–4) | 1 (1–2) | 0.185c |
| Time from index surgery to first steroid course, yr, median (P25–P75)b | 2.5 (0.5–5.1) | 3.5 (0.8–7.8) | 2.3 (0.2–3.5) | 0.171c |
| Immunosuppressive (IS), n (%) | ||||
| Start IS, n (%) | 40 (39) | 12 (41) | 28 (38) | 0.740a |
| Time from index surgery to IS, yr, median (P25–P75)b | 1.0 (0.1–5.3) | 5.8 (0.6–7.7) | 0.5 (0.1–3.3) | 0.028c |
| Change IS, n (%) | 7 (7) | 2 (7) | 5 (7) | >0.999a |
| Time from index surgery to change IS, yr, median (P25–P75)b | 3.6 (1.5–4.2) | 4.3 (4.0–4.5) | 2.0 (1.5–3.6) | 0.121c |
| BT, n (%) | ||||
| Start BT, n (%) | 40 (39) | 14 (48) | 26 (35) | 0.218a |
| Time from index surgery to BT, yr, median (P25–P75)b | 5.7 (2.1–8.5) | 8.6 (1.5–12.0) | 5.3 (2.5–7.5) | 0.187c |
| Change BT, n (%) | 25 (24) | 7 (24) | 18 (24) | 0.984a |
| Time from index surgery to change BT, yr, median (P25-P75)b | 4.0 (2.4–8.7) | 8.5 (4.0–13.2) | 4 (1.5–7.6) | 0.079c |
| New event, n (%) | ||||
| Stricturing, n (%) | 23 (22) | 10 (35) | 13 (18) | 0.072a |
| Time from index surgery to new stricturing, yr, median (P25–P75)b | 3.0 (1.0–6.0) | 4.2 (2.5–7.2) | 2.2 (1.0–5.0) | >0.999c |
| Penetrating, n (%) | 6 (6) | 0 (0) | 6 (8) | 0.181a |
| Time from index surgery to new penetrating, yr, median (P25–P75)b | 2.2 (0.6–3.5) | — | 2.2 (0.6–3.5) | — |
| Perianal, n (%) | 2 (2) | 1 (3) | 1 (1) | >0.999a |
| Time from index surgery to new perianal, yr, median (P25–P50)b | 2.2 (2.0–2.5) | 2.5 (2.5–2.5) | 2.0 (2.0–2.0) | >0.999a |
| Progressive disease, n (%) | 75 (73) | 23 (79) | 52 (70) | 0.354a |
Bold entries indicate significant P values (P < 0.05).
BT, biologic therapy; IS, immunosuppressive.
a
χ2 test.
b
Time from index surgery to each outcome is considered only for patients presenting the outcome.
c
Mann-Whitney test.