Table 5.
Histopathological scoring per section and Crohn's disease phenotype: stricturing (B2) vs penetrating without associated stricture (B3o) vs penetrating with associated stricture (B3s)
| B2 (n = 29), n (%) | B3s (n = 54), n (%) | B3o (n = 20), n (%) | Pa | Pb | Pc | |
| Margins | ||||||
| Inflammationd | >0.999 | 0.015 | 0.044 | |||
| 1–2 | 21 (81) | 35 (71) | 7 (39) | |||
| 3 | 5 (19) | 14 (29) | 11 (61) | |||
| Fibrosis | 0.303 | >0.999 | 0.645 | |||
| 0 | 3 (10) | 13 (24) | 2 (10) | |||
| 1 | 26 (90) | 41 (76) | 18 (90) | |||
| Total scored | 0.627 | 0.081 | 0.792 | |||
| ≤2 | 17 (65) | 22 (50) | 5 (28) | |||
| 3 | 4 (15) | 15 (28) | 3 (17) | |||
| 4–5 | 5 (19) | 12 (22) | 10 (56) | |||
| Inflamed | ||||||
| Inflammation | 0.067 | 0.006 | >0.999 | |||
| 1–2 | 7 (24) | 3 (6) | 0 (0) | |||
| 3 | 22 (76) | 51 (94) | 20 (100) | |||
| Fibrosis | 0.234 | >0.999 | 0.108 | |||
| 0 | 2 (7) | 0 (0) | 2 (10) | |||
| 1 | 22 (76) | 38 (70) | 15 (75) | |||
| 2 | 5 (17) | 16 (30) | 3 (15) | |||
| Total score | 0.024 | >0.999 | >0.999 | |||
| ≤2 | 1 (4) | 0 (0) | 0 (0) | |||
| 3 | 7 (24) | 3 (6) | 2 (10) | |||
| 4–5 | 21 (72) | 51 (94) | 18 (90) | |||
| Most affected | ||||||
| Inflammation | 0.033 | 0.039 | 0.688 | |||
| 1–2 | 13 (45) | 10 (19) | 6 (30) | |||
| 3 | 16 (55) | 44 (81) | 14 (70) | |||
| Fibrosis | >0.999 | >0.999 | >0.999 | |||
| 0 | 0 (0) | 0 (0) | 1 (5) | |||
| 1 | 26 (90) | 50 (93) | 18 (90) | |||
| 2 | 3 (10) | 4 (7) | 1 (5) | |||
| Total score | 0.060 | >0.999 | >0.999 | |||
| ≤2 | 5 (17) | 2 (4) | 2 (10) | |||
| 3 | 8 (28) | 8 (15) | 4 (20) | |||
| 4–5 | 16 (55) | 44 (81) | 14 (70) |
Bold entries indicate significant P values (P < 0.05).
Inflammation (1–3) and fibrosis (0–2) scoring: Higher scores indicate more severe inflammation and fibrosis, respectively (23).
a
P value for B2 vs B3s with Bonferroni correction.
b
P value for B2 vs B3o with Bonferroni correction.
c
P value for B3o vs B3s with Bonferroni correction.
d
Does not include patients without inflammation (n = 93).