Table 4.
Levels of T cell number and proinflammatory cytokines of 127 children or adolescence with COVID-19 in different age stages. Values are medians (interquartile ranges) unless stated otherwise.
| Total | ≤24m | >25 m, ≤5y | >5, <=10y | >10y | |
|---|---|---|---|---|---|
| CD3+T cell proportion (38.56–70.06%) | 68.09 [63.61–72.95] | 66.44 [59.76–75.26] | 65.66 [59.87–67.23] | 68.97 [64.06–72.35] | 69.98 [65.31–73.79] |
| CD3+T cell number (805–4459cell/L) | 2073 [1675–2779] | 3234 [2329–4403] | 2426 [2082–3617] | 1971 [1647–2287] | 1868 [1554–2267] |
| CD3+CD4+T cell proportion (14.21%−36.99%) | 35.81 [30.78–39.19] | 41.81 [35.95–46.25] | 30.79 [27.96–35.52] | 35.90 [30.63–39.18] | 32.10 [28.74–36.86] |
| CD3+CD4+T cell number (345–2350cell/L) | 1012 [669–1569] | 2033.5 [1757–2456] | 1205 [891–1403] | 970 [670–1123] | 740 [610–904] |
| CD3+CD8+T cell proportion (13.24%−38.53%) | 27.52 [21.84–31.49] | 23.46 [18.09–27.52] | 27.72 [22.54–30.91] | 27.07 [22.13–31.12] | 28.80 [26.10–31.92] |
| CD3+CD8+T cell number (314–2080cell/L) | 743 [556–1022] | 1100 [716–1281] | 1010 [788–1590] | 698 [481–983] | 707 [513–759] |
| Natural killer proportion (7.92%−33.99%) | 9.97 [5.71–14.59] | 5.905 [4.73–8.54] | 12.21 [4.44–18.91] | 11.04 [6.05–13.43] | 9.81 [6.20–16.52] |
| Natural killer cell number (210–1514cell/L) | 316 [187–470] | 289 [220–425] | 437 [308–696] | 316 [197–407] | 282 [145–476] |
| Lymphocyte (25%−40%) | 18.15 [15.35–22.61] | 21.37 [17.04–28.14] | 19.96 [17.53–27.79] | 17.69 [15.09–20.22] | 16.19 [14.09–20.69] |
| CD19+B cell number (240–1317 cell/L) | 557 [372–822] | 999 [725–1687] | 799 [534–1204] | 538 [358–651] | 408 [329–540] |
| CD4+/CD8+T ratio (0.96–2.05) | 1.34 [1.09–1.78] | 1.87 [1.44–2.68] | 1.34 [1.22–1.81] | 1.30 [1.10–1.61] | 1.14 [0.91–1.39] |
| CD4+CD25+T cell proportion (%) | 4.93 [3.64–5.70] | 4.86 [3.53–5.59] | 4.51 [3.68–5.02] | 4.65 [3.12–5.77] | 5.34 [4.38–6.75] |
| Human IL-2 (0–11.4pg/ml) | 1.43 [1.21–1.67] | 1.40 [1.27–1.69] | 1.52 [1.27–1.65] | 1.47 [1.25–1.95] | 1.36 [1.18–1.50] |
| Human IL-4 (0–12.9pg/ml) | 2.68 [2.07–3.33] | 2.72 [1.78–3.29] | 2.53 [2.36–2.94] | 2.58 [2.09–3.43] | 2.71 [2.16–3.24] |
| Human IL-6 (0–20.9pg/ml) | 3.98 [3.04–5.66] | 4.36 [3.51–7.33] | 3.43 [2.71–5.13] | 4.14 [3.14–6.63] | 3.70 [3.06–4.97] |
| Human IL-10 (0–5.9pg/ml) | 3.50 [3.05–4.61] | 4.53 [3.47–7.08] | 3.60 [3.01–4.35] | 3.71 [3.11–5.00] | 3.19 [2.79–3.49] |
| Human TNF-α (0–5.5pg/ml) | 1.62 [1.26–2.23] | 1.80 [1.43–2.40] | 1.65 [1.28–1.93] | 1.63 [1.27–2.68] | 1.50 [0.92–1.83] |
| Human IFN-γ (0–17.3pg/ml) | 2.87 [2.23–3.91] | 3.01 [2.57–3.80] | 3.14 [2.54–4.06] | 2.78 [2.11–4.78] | 2.81 [1.85–3.38] |