Figure 5.

Working principles of E7 vaccination prior to tumor resection.a: When E7 vaccination is performed after tumor cell injection, circulating E7-specific CD8⁺ T-cells are induced. However, these cells cannot infiltrate the tumor which continues to grow. b: After resection of primary tumors, residual tumor cells can regrow resulting in tumor recurrence. c: Primary tumor resection performed after E7 vaccination allows circulating E7-specific CD8⁺ T-cell to infiltrate the residual tumor cells and efficiently control the tumor, thus impeding tumor recurrence