Table 4. Diagnostic performance of WBC count, CRP, PCT, and MDW for predicting sepsis according to immune status.
| MDW | CRP | PCT | WBC count | |
|---|---|---|---|---|
| Immune-compromisedc (n = 307) | ||||
| AUC (95% CI) | 0.66 (0.60–0.72) | 0.66 (0.60–0.72) | 0.70 (0.64–0.76) | 0.56 (0.50–0.63)* |
| Cutoff value | 22.0a | 4.0a | 0.05a | <4000/μL or >12,000/μLb |
| Sensitivity (95% CI) | 73.3 (64.9–80.6) | 70.2 (61.6–77.9) | 74.1 (65.7–81.3) | 48.9 (40.0–57.7) |
| Specificity (95% CI) | 55.1 (47.5–62.6) | 55.7 (48.0–63.1) | 56.3 (48.6–63.7) | 63.1 (55.5–70.2) |
| Immune-competentd (n = 242) | ||||
| AUC (95% CI) | 0.73 (0.66–0.80) | 0.82 (0.76–0.88) | 0.80 (0.77–0.88) | 0.67 (0.62–0.76) |
| Cutoff value | 19.0a | 4.0a | 0.05a | <4000/μL or >12,000/μLb |
| Sensitivity (95% CI) | 82.5 (70.1–91.3) | 67.4 (54.8–80.1) | 82.5 (70.1–91.3) | 50.9 (37.3–64.4) |
| Specificity (95% CI) | 57.8 (50.4–65.1) | 77.8 (71.2–83.6) | 78.3 (71.6–84.0) | 81.6 (75.3–86.9) |
MDW, monocyte distribution width; WBC, white blood cell; CRP, C-reactive protein; PCT, procalcitonin; CI, confidence interval.
aThe cutoff value was adopted from the value maximizing Youden’s index.
bThe cutoff value for WBC count was adapted from the definition of systemic inflammatory response syndrome.
cImmune-competent was defined as patients not immune-compromised.
dImmune-compromised is defined as patients with any malignancy, who were treated with G-CSF, with neutropenia, who underwent organ transplantation, or with acquired immunodeficiency syndrome.
*The AUC is significantly different from that of MDW.